The effect of islet amyloid polypeptide (amylin) and calcitonin gene-related peptide on glucose removal in the anaesthetized rat and on insulin secretion from rat pancreatic isletsin vitro |
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| Authors: | Alison E. Tedstone Tania Nezzer Stephen J. Hughes Anne Clark David R. Matthews |
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| Affiliation: | (1) Metabolic Research Laboratory, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Woodstock Road, OX2 6HE Oxford, UK;(2) Diabetes Research Laboratories, Radcliffe Infirmary, Woodstock Road, OX2 6HE Oxford, UK;(3) Nuffield Department of Clinical Biochemistry, John Radcliffe Hospital, Headley Way, Headington, OX3 9DU Oxford, UK |
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| Abstract: | The effect of intravenous infusion of islet amyloid polypeptide (IAPP/amylin) and calcitonin gene-related peptide (CGRP) on blood glucose and plasma insulin in the basal and glucose-stimulated state was investigated in the anaesthetized rat. Both peptides had no effect on basal blood glucose or plasma insulin but following an intravenous bolus of glucose, CGRP-treated rats were hyperglycaemic and hyperinsulinaemic compared with control animals which were similar to IAPP-treated rats. IAPP had no effect on glucose-stimulated islet insulin secretion. These results suggest that CGRP, but not IAPP, alters glucose removalin vivo. |
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| Keywords: | CGRP IAPP/amylin glucose removal insulin release |
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