The interface between medically assisted reproduction and genetics: technical, social, ethical and legal issues* |
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| Authors: | Soini Sirpa; Ibarreta Dolores; Anastasiadou Violetta; Ayme Segolene; Braga Suzanne; Cornel Martina; Coviello Domenico A; Evers-Kiebooms Gerry; Geraedts Joep; Gianaroli Luca; Harper Joyce; Kosztolanyi Gyorgy; Lundin Kersti; Rodrigues-Cerezo Emilio; Sermon Karen; Sequeiros Jorge; Tranebjaerg Lisbeth; Kaariainen Helena |
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1 Department of Medical Genetics, University of Turku, Turku, 2 Medical and Biolaw, University of Helsinki, Helsinki, Finland, 3 European Commission’s Joint Research Center, Seville, Spain, 4 Clinical Genetics Department, Archbishop Hospital and Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus, 5 INSERM, Paris, France, 6 SGMG/SSGM, Bern, Switzerland, 7 VU University Medical Center, Amsterdam, The Netherlands, 8 Laboratory of Medical Genetics, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano, Italy, 9 Psychosocial Genetics Unit, University Hospital – University of Leuven, Leuven, Belgium, 10 Department of Clinical Genetics, University Hospital Maastricht, Maastricht, The Netherlands, 11 SISMeR, Centre for Reproductive Medicine, Bologna, Italy, 12 UCL Centre for PGD, London, UK, 13 Department of Medical Genetics, University of Pécs, Pécs, Hungary, 14 SU/Sahlgrenska, Göteborg, Sweden, 15 Centre for Medical Genetics, Dutch-speaking Brussels Free University, Brussels, Belgium, 16 Department of Human Genetics, University of Porto, Porto, Portugal, 17 Department of Audiology, H:S Bispebjerg Hospital and Wilhem Johannsen Centre of Functional Genomics, University of Copenhagen, Copenhagen, Denmark and 18 Department of Medical Genetics, University of Turku, Turku, Finland
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| Abstract: | 19 To whom correspondence should be addressed at: Department of Medical Genetics, University of Turku, Kiinamyllykatu 10, FIN-20520 Turku, Finland. E-mail: hkaaria{at}utu.fi* Reprinted from European Journal of Human Genetics (2006) 1–58 with permission. The views expressed in this study do not necessarily reflect those of the European Commission (EC). The interface between assisted reproductive technologies (ART)and genetics comprises several sensitive and important issuesthat affect infertile couples, families with severe geneticdiseases, potential children, professionals in ART and genetics,health care, researchers and the society in general. Geneticcauses have a considerable involvement in infertility. Geneticconditions may also be transmitted to the offspring and hencecreate transgenerational infertility or other serious healthproblems. Several studies also suggest a slightly elevated riskof birth defects in children born following ART. PGD has becomewidely practiced throughout the world for various medical indications,but its limits are being debated. The attitudes towards ARTand PGD vary substantially within Europe. The purpose of thisarticle was to outline a framework for development of guidelinesto be issued jointly by European Society of Human Genetics (ESHG)and European Society of Human Reproduction and Embryology (ESHRE)for the interface between genetics and ART. Technical, social,ethical and legal issues of ART and genetics will be reviewed. |
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| Keywords: | assisted reproductive technology birth defects counselling genetic diseases infertility PGD |
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