|
|||||
|
|
The malate synthase of Paracoccidioides brasiliensis is a linked surface protein that behaves as an anchorless adhesin |
|
| Authors: | Benedito Rodrigues da Silva Neto Julhiany de Fátima da Silva Maria José Soares Mendes-Giannini Henrique Leonel Lenzi Célia Maria de Almeida Soares Maristela Pereira |
| Affiliation: | (1) Laborat?rio de Biologia Molecular, Departamento de Bioqu?mica e Biologia Molecular, Instituto de Ci?ncias Biol?gicas, Universidade Federal de Goi?s, C.P. 131, 74001-970 Goi?nia, GO, Brazil;(2) Laborat?rio de Micologia Cl?nica, Universidade Estadual Paulista, UNESP, Araraquara, SP, Brazil;(3) Laborat?rio de Patologia, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brazil |
| Abstract: | BackgroundThe pathogenic fungus Paracoccidioides brasiliensis is the agent of paracoccidioidomycosis (PCM). This is a pulmonary mycosis acquired by inhalation of fungal airborne propagules that can disseminate to several organs and tissues leading to a severe form of the disease. Adhesion and invasion to host cells are essential steps involved in the internalization and dissemination of pathogens. Inside the host, P. brasiliensis may use the glyoxylate cycle for intracellular survival. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |