Twenty-five loci form a continuous linkage map of markers for human chromosome 7 |
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| Authors: | G Mark Lathrop Peter O'Connell Mark Leppert Yusuke Nakamura Martin Farrall Lap-Chee Tsui Jean-Marc Lalouel Ray White |
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| Institution: | Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City 84132. |
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| Abstract: | We have constructed a primary genetic linkage map from DNA markers that define 25 loci on chromosome 7. The markers form a continuous linkage group of 141 cM in males and 340 cM in females; female genetic distances were on average more than twofold higher than those in males throughout the chromosome. The average heterozygosity of the loci was 45%. A subset of the markers can be used for efficient application of this map to studies of human genetic disease. |
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