Steroidal saponins from the fresh tubers of Ophiopogon japonicus |
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| Institution: | 1. Ovation Health Science and Technology Co., Ltd., ENN Group, Langfang 065001, PR China;2. Beijing Institute of Radiation Medicine, Beijing 100850, PR China;1. School of Pharmacy, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia;2. School of Pharmacy, Centre for Biomolecular Sciences, The University of Nottingham, University Park, Nottingham, NG7 2RD, UK;3. School of Biosciences, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia;4. Institute of Biological Sciences, University of Malaya, 50603 Kuala Lumpur, Malaysia;5. Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia;1. Laboratory of Natural Products Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon;2. Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan;3. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan;1. Centre for Functional Ecology, Department of Life Sciences, University of Coimbra, 3000-456 Coimbra, Portugal;2. Departamento de Bioloxía Vexetal e Ciencia do Solo, Universidade de Vigo, E-36310 Vigo, Spain;3. Departamento de Química Orgánica, Universidade de Vigo, E-36310 Vigo, Spain;1. Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan;2. Gifu Prefectural Institute for Health and Environmental Sciences, Naka-fudogaoka, Kakamigahara, Gifu 504-0838, Japan;1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China;2. Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Cai Lun Lu 1200, Shanghai 201203, PR China;3. School of Chinese Medicine, Hong Kong Baptist University, Kowloon Town 999077, Hong Kong Special Administrative Region;4. Chongqing Academy of Chinese Materia Medica, Chongqing 400065, PR China;5. Experimental Center of Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China |
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| Abstract: | Eleven novel furostanol saponins, named ophiofurospisides C–E, G–N (1–3, 5–12), one new spirostanol saponin, named ophiopogonin R (13), were isolated from the fresh tubers of Ophiopogon japonicus. Their structures were determined on the basis of spectroscopic techniques (1D and 2D NMR) and HRESIMS. The isolated furostanol saponins possessed two sugar chains located at C-3 and C-26, respectively. Six furostanol saponins (1, 5–9) with disaccharide moiety linked at position C-26 of the aglycone were rare in the plant kingdom. |
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| Keywords: | Furostanol saponin Spirostanol saponin |
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