Two new compounds with antimicrobial activities from the seeds of Voacanga africana |
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Institution: | 1. Pamukkale University, Faculty of Engineering, Department of Chemical Engineering, 20070 Denizli, Turkey;2. Pamukkale University, Faculty of Science, Department of Chemistry, 20017 Denizli, Turkey;3. Pamukkale University, Faculty of Education, Department of CITE, 20017 Denizli, Turkey |
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Abstract: | Two new compounds, (R)-4-(2-methylpentyl)-4H-dithieno2,3-b:3′,2′-e]pyran (1) and 4-(2-ethylbutyl)-4H-dithieno2,3-b:3′,2′-e]pyran (2) were extracted from the seeds of Voacanga africana. The molecular structures of these compounds were measured with the help of broad spectroscopic (1D and 2D-NMR, IR, ESI-TOF-MS, HR-MS) analyses. The primary pharmacological operations of these compounds were brought to evaluation by applying the antibacterial extrasomatic test. The results revealed that compound 1 and 2 were in an effective position to stop the growth of Escherichia coli, Streptococcus and Salmonella typhi. On the other hand, the inhibitory impacts on Staphylococcus aureus as well as Pseudomonas aeruginosa were not apparent. |
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Keywords: | Thiophene compounds Voacanga Antibiotic |
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