Dianthus erinaceus var. erinaceus: Extraction,isolation, characterization and antimicrobial activity investigation of novel saponins |
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| Institution: | 1. Department of Chemistry, Faculty of Science, Ege University, 35100, Bornova-Izmir, Turkey;2. Department of Biology, Faculty of Science, Ege University, 35100, Bornova-Izmir, Turkey;1. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, PR China;2. School of Life Sciences, Jilin Agricultural University, Changchun 130118, China;3. Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Wanning 571533, China;4. Key Laboratory of Plant Resources Conservation andUtilization, College of Hunan Province, Jishou University, Jishou 416000, China;1. Department of Plant Science, Faculty of Biological Sciences, Alzahra University, Vanak, Tehran, Iran;2. Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Vanak, Tehran, Iran;1. Batterjee Medical College, Preparatory Year Program, Jeddah, 21442, Saudi Arabia;2. Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt;3. Department of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia;4. Department of Biology, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia;5. Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al-Madinah, Al-Munawwarah, 30078, Saudi Arabia;6. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt;7. Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia;8. Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt;9. Faculty of Dentistry, British University, El Sherouk City, Suez Desert Road, Cairo, 11837, Egypt;10. Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt;1. Department of Food Science and Technology, Science and Research Branch, Islamic Azad University, Tehran, Iran;2. Department of Food Hygiene, Tabriz Branch, Islamic Azad University, Tabriz, Iran;3. School of Energy and Chemical Engineering, Xiamen University Malaysia, Jalan Sunsuria, Bandar Sunsuria, 43900 Sepang, Selangor Darul Ehsan, Malaysia;4. Master''s Program of Green Energy Science and Technology, Feng Chia University, No. 100, Wenhwa Road, Seatwen, Taichung 40724, Taiwan;5. General Education Center, Feng Chia University, No. 100, Wenhwa Road, Seatwen, Taichung 40724, Taiwan;6. Green Energy and Biotechnology Industry Research Center, Feng Chia University, No. 100, Wenhwa Road, Seatwen, Taichung 40724, Taiwan;7. Department of Chemical and Environmental Engineering, Faculty of Science and Engineering, University of Nottingham Malaysia, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia;8. Faculty of Chemical Engineering, Sahand University of Technology, Tabriz 51335-1996, East Azarbaijan, Iran;9. School of Engineering, Faculty of Science and Engineering, University of Waikato, Hamilton 3240, New Zealand;1. State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, People’s Republic of China;2. School of Biotechnology and Chemical Engineering, Ningbo Institute of Technology, Zhejiang University, Ningbo, 315100, People’s Republic of China |
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| Abstract: | A phytochemical analysis of Dianthus erinaceus Boiss. var. erinaceus (Caryophyllaceae) has led to the isolation of two novel triterpenoid saponins, containing an oleane type skeleton, named dianosides K and L (1, 2), along with six known triterpenoid saponins (3–8). On the basis of chemical and spectrometric data, the structures of the new compounds were elucidated as 3-O-β-d-glucopyranosyl (1 → 3)]–β-d-glucopyranosyl (1 → 6)]-β-d-glucopyranosyl-olean-12-ene-23α,28-β–dioic acid 28-O-β-d-glucopyranosyl ester (1) and 3-O-β-d-glucopyranosyl (1 → 3)]–β-d-glucopyranosyl(1 → 6)]-β-d-glucopyranosyl-olean-12-ene-23α,28-β-dioic acid 28-O-α-l-mannopyranosyl (1 → 6)-β-d-glucopyranosyl ester (2). All isolated natural compounds were structurally characterized by 1D- (1H, 13C, DEPT); 2D- (COSY, HMQC, HMBC) NMR and HR-ESI/MS methods. The antimicrobial activity of compounds 1 and 2 were tested against four Gram-negative, three Gram-positive bacteria and the yeast Candida albicans by the MIC method. |
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| Keywords: | Dianoside K Dianoside L Triterpenoid saponin Caryophyllaceae Antimicrobial activity |
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