Six new cassane diterpenoids from the seeds of Caesalpinia sappan |
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| Institution: | 1. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China;2. Department of Pharmaceutical Engineering, Hunan University of Science and Engineering, Yongzhou 425199, China;3. Institute of Botany, Jiangsu Province and Chinese Academy of Science, Nanjing 210014, China |
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| Abstract: | Six new cassane diterpenoids (1–6) and 15 known compounds were isolated and identified from the seeds of Caesalpinia sappan. The structures of the new compounds were determined based on the spectroscopic methods, including 1D and 2D NMR techniques. Compound 1 is a rare cassane diterpenoid featuring a nitrogen containing bridge between C-19 and C-20. Compounds 1 and 2 exhibited moderate cytotoxicity against HCT116, AGS, and HepG2 cell lines with IC50 values ranging from 6.36 to 27.86 μM. |
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| Keywords: | Leguminosae Cassane diterpenoids Cytotoxicity |
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