Cucurbitane-type triterpenoids from the aerial parts of Momordica charantia L. |
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| Institution: | 1. School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei 230009, Anhui Province, China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan Province, China;1. College of Bioengineering, Beijing Polytechnic, Beijing 100029, China;2. College of Pharmacy, Dalian Medical University, Dalian 116044, China;3. The Second Affiliated Hospital of Dalian Medical University, Dalian 116044, China;1. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, PR China;2. School of Life Sciences, Jilin Agricultural University, Changchun 130118, China;3. Hainan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Wanning 571533, China;4. Key Laboratory of Plant Resources Conservation andUtilization, College of Hunan Province, Jishou University, Jishou 416000, China;1. Graduate School of Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan;2. Research Institute of Green Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan;3. Graduate School of Agriculture, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan;1. Key Laboratory for Forest Resources Conservation and Use in the Southwest Mountains of China, Southwest Forestry University, Kunming 650224, China;2. School of Pharmacy, Wannan Medical College, Wuhu 241002, China;1. Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China;2. Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, PR China;3. School of Applied and Chemical Engineering, Xichang College, Xichang 615000, PR China |
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| Abstract: | Six new cucurbitane-type triterpenoids (1–6), together with two known analogues (7 and 8) were isolated from the aerial parts of Momordica charantia L. The structures of new compounds were identified as cucurbita-6,24-dien-3β,23-diol-19,5β-olide (1), (19R)-5β,19-epoxy-19-methoxycucurbita-6,24-dien-3β,23-diol (2), (19S)-5β,19-epoxy-19-methoxycucurbita-6,24-dien-3β,23-diol (3), (19R)-5β,19-epoxy-19-isopropoxycucurbita-6,24-dien-3β,23-diol (4), 3β,23-dihydroxy-5-methoxycucurbita-6,24-dien-19-al (5) and (19R)-7β,19-epoxy-19-methoxycucurbita-5,24-dien-3β,23-diol (6), by extensive MS, 1D and 2D NMR spectroscopic technologies. This is the first report of the isolation of tetracyclic triterpenoids possessing a 7β,19-epoxy system, viz., 6, from M. charantia L. |
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| Keywords: | Cucurbitane-type triterpenoids |
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