Cytotoxic prenylated xanthone and coumarin derivatives from Malaysian Mesua beccariana |
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| Institution: | 1. Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia;2. Laboratory of Natural Products, Institute of Biosience, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia;3. Makna Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia;1. Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata 700064, India;2. Department of Agricultural Biotechnology, School of Agriculture and Rural Development, Ramakrishna Mission Vivekananda University, Ramakrishna Mission Ashram Narendrapur, Kolkata 700103, India;3. AICRP on Groundnut, Directorate of Research, Bidhan Chandra Krishi Viswavidyalaya, Kalyani, Nadia, West Bengal 741235, India;1. G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoku 159, Vladivostok 690022, Russian Federation;2. Far Eastern Federal University, Suhanova Street 8, Vladivostok 690950, Russian Federation;3. Institute of Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoku 159, Vladivostok 690022, Russian Federation;1. Department of Chemistry, Faculty of Science, Chiang Mai University, Sutep, Muang, Chiang Mai, 50200, Thailand;2. Natural Products Research Laboratory, School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai, 57100, Thailand;3. Medical Molecular Biology Research Unit, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Thailand Science Park, Pathum Thani, 12120, Thailand;4. School of Chemistry, University of Wollongong, Wollongong, New South Wales, 2522, Australia;1. Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China;2. Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, PR China;3. University of Chinese Academy of Sciences, 100049, Beijing, PR China |
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| Abstract: | Our recent research on the phytochemical constituents of the stem bark of Mesua beccariana gave one new xanthone, beccarixanthone T (1) and one new coumarin, beccamarin T (2) together with three known xanthones mesuarianone (3), mesuasinone (4), 1,5-dihydroxyxanthone (5) and four known terpenoids, friedelin (6), stigmasterol (7), beta-sitosterol (8) and gamma-sitosterol (9). The structures of these compounds were elucidated and determined using spectroscopic techniques such as NMR and MS. The cytotoxic activities of compounds 1-4 as well as the crude extracts were tested against two cancer cell lines, Hep G2 (liver cancer cell line) and HT-29 (colon cancer cell line) using MTT assays. Mesuarianone (3) gave a significant activity on the HT-29 cell line while mesuasinone (4) gave moderate activity against HT-29 cell line. |
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| Keywords: | Coumarin Xanthone Cytotoxic |
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