Antimicrobial lignans derived from the roots of Streblus asper |
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| Institution: | 1. State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry & Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, PR China;2. Peoples’ Hospital of Pubei, Pubei 535300, PR China;3. Guangxi Key Laboratory for Traditional Chinese Medicine Quality Standards, Nanning 530022, PR China, PR China;1. Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon;2. Department of Pharmacognosy, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria;3. Department of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria;4. Institute of Organic Chemistry, University of Vienna, Währingerstraße 38, A-1090 Vienna, Austria;5. Department of Biotechnology, University of Natural Resources and Life Sciences Vienna, Muthgasse 18, A-1190 Vienna, Austria;1. Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, PR China;2. Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China;3. Chemistry and Chemical Engineering College, Chongqing University, Chongqing 400030, PR China;4. University of the Chinese Academy of Sciences, Beijing 100049, PR China;1. Dipartimento di Matematica, Università degli Studi di Milano, via Saldini 50, 20133 Milano, Italy;2. Departement of Mathematics and Namur Center for Complex Systems - naXys, University of Namur, 8 Rempart de la Vierge, B5000 Namur, Belgium;1. Pharmacognosie et Molécules Naturelles Bioactives, Laboratoire d’Innovation Thérapeutique, UMR 7200, CNRS-Université de Strasbourg, Faculté de Pharmacie, 74 Route du Rhin, F-67401 Illkirch Cedex, France;2. Laboratoire de Pharmacochimie des Substances Naturelles, Département de Chimie Organique, Faculté de Sciences, Université de Yaoundé, BP 812, Yaoundé, Cameroon;3. Laboratoire de Chimie Thérapeutique, UMR7312, 51 Rue Cognacq-Jay, 51100 Reims, France;1. School of Marine Sciences, Sun Yat-Sen University, Guangzhou 510006, China;2. School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China;3. College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524025, China;4. South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Sun Yat-Sen University, Guangzhou 510275, China;1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (CAS), Kunming 650204, PR China;2. Graduate University of Chinese Academy of Sciences, Beijing 100049, PR China;3. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kuming 650500, PR China |
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| Abstract: | Four new lignans, (7′R,8′S)-4,4'-Dimethoxy-strebluslignanol (1), 3'-Hydroxy-isostrebluslignaldehyde (2), 3,3'-Methylene-bis(4-hydroxybenzaldehyde) (3), and 4-Methoxy-isomagnaldehyde (4), and six known lignans (5–10), were isolated from the roots of Streblus asper. The structures of these molecules were elucidated through various spectroscopic methods of analysis, including 1D and 2D NMR. The stereochemistry at the chiral centres was determined using the CD spectrum and from coupling constant and optical rotation data. Compounds 1–6 showed good antimicrobial activity against Saccharomyces cerevisiae (ATCC 9763), Bacillus subtilis (ATCC 6633), Pseudomonas aeruginosa (ATCC 9027), Escherichia coli (ATCC 11775), and Staphylococcus aureus (ATCC 25923), with MIC values ranging from 0.0150 to 0.0940 μM. |
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| Keywords: | 3'-Hydroxy-isostrebluslignaldehyde 3 3'-Methylene-bis(4-hydroxybenzaldehyde) 4-Methoxy-isomagnaldehyde Antimicrobial |
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