Two new flavonoid glycosides from Iris tectorum |
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| Institution: | 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China;2. Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of TCM, China Pharmaceutical University, Nanjing 211198, People’s Republic of China;1. Department of Traditional Chinese Orthopedics, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;2. Department of Emergency Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;3. Department of Rheumatology and Immunology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;1. Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan;2. Department of Biomedical Information Sciences, Graduate School of Information Sciences, Hiroshima City University, 3-4-1 Ozuka-Higashi, Asa-Minami-Ku, Hiroshima 731-3194, Japan;1. University College Dublin, Ireland;2. LIP6, UPMC, Paris, France;3. Université Paris-Est, ESYCOM, ESIEE Paris, Noisy-Le-Grand, France;1. Jiangxi Engineering Laboratory for Optoelectronics Testing Technology, Nanchang Hangkong University, Nanchang 330063, China;2. Optical Technology Research Laboratory, Victoria University, P.O. Box 14428, Melbourne, Victoria 8001, Australia;3. Department of Physics, University of Science and Technology of China, Hefei 230026, China;1. School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, People''s Republic of China;2. School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, People''s Republic of China |
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| Abstract: | Phytochemical investigation of the ethanol extract of rhizomes of Iris tectorum resulted in the isolation and characterization of two new flavonoid glycosides, tectorigenin-7-O-β-d-fucopyranoside (1), 3,5,4′-trihydroxy-7,3′-dimethoxyflavanone-5-O-α-l-rhamnopyranoside (2), together with two known ones (3, 4). The rhamnose substituent at C-5 displayed uncommon connection in naturally occurring flavonoid glycosides. Their structures were elucidated on the basis of extensive spectroscopic analysis. All of the isolates were evaluated for their in vitro inhibitory activity against aldose reductase. |
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| Keywords: | Flavonoid glycosides Aldose reductase |
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