Gout prophylactic constituents from the flower buds of Lonicera japonica |
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| Affiliation: | 1. Department of Traditional Chinese Orthopedics, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;2. Department of Emergency Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;3. Department of Rheumatology and Immunology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;1. Lund University, Department of Chemistry, Centre for Analysis and Synthesis, SE-221 00 Lund, Sweden;2. Lund University, Department of Chemical Engineering, Centre for Chemistry and Chemical Engineering, Lund, Sweden;1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China;2. Jiangsu Provincial Key Laboratory for TCM Evaluation and Translational Development, School of TCM, China Pharmaceutical University, Nanjing 211198, People’s Republic of China;1. Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun 666303, PR China;2. University of Chinese Academy of Sciences, Beijing 100049, PR China;3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China;4. School of Pharmacy, Guiyang Medical College, Guiyang 550004, PR China;5. Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Ministry of Education, Guiyang 550004, PR China;1. School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, People’s Republic of China;2. Department of Pharmacy, General Hospital of Guangzhou Military Command, Guangzhou 510010, People’s Republic of China;3. Centre Laboratory, Guangdong Pharmaceutical University, Guangzhou 510006, People’s Republic of China;1. Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China;2. College of Pharmacy and Chemistry, Dali University, Dali 671000, PR China |
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| Abstract: | Two new sesquiterpene glycosides (R)-dehydroxyabscisic alcohol β-d-apiofuranosyl-(1″ → 6′)-β-d-glucopyranoside (1) and (−)-(1S,2R,6R,7R)-1,2,6-trimethyl-8-hydroxy methyltricyclic[5.3.1.02,6]-undec-8-en-10-one β-d-apiofuranosyl-(1″ → 6′)-β-d-glucopyranoside (2), were isolated from the flower buds of Lonicera japonica. Their structures were determined by spectroscopic and chemical methods. Compound 2 could significantly decrease monosodium urate-mediated cytokine production from activated macrophage through lowering IL-1β and TNFα. |
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| Keywords: | Sesquiterpene glycoside Gout Monosodium urate |
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