Cytotoxic and antimalarial constituents from aerial parts of Sphaeranthus indicus |
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| Institution: | 1. A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilov Street, 28, 119991 Moscow, Russia;2. A.V. Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine, Lustdorfskaya Road, 86, 65080 Odessa, Ukraine;1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;2. Development and Utilization Key Laboratory of Northeast Plant Materials, Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China;1. School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China;2. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China;3. Department of Human Resources, Hebei North University, Zhangjiakou 075000, China |
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| Abstract: | Two new eudesmanolide type sesquiterpenes, indicusalactone (1) and (?)?-?oxyfrullanolide (2), along with twelve known compounds (3?14), were isolated from the aerial parts of Sphaeranthus indicus. The structures of these compounds were established on the basis of their 1D and 2D NMR spectroscopic data. Compounds 1?4 and 12?14 showed antimalarial activity against Plasmodium falciparum with IC50 values ranging from 2.32 to 6.47μg/mL. In addition, compounds 2?5 showed cytotoxicity against cancer cell lines, KB, NCI-H187 and MCF-7 with IC50 values within the range 1.23?46.19 μg/mL. |
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| Keywords: | Asteraceae Eudesmanolide Frullanolide Antimalarial Cytotoxicity |
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