Anti-neuroinflammatory constituents from Sinomenium acutum rhizomes |
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| Institution: | 1. Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea;2. Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, Republic of Korea;3. Korea Food Research Institute, 516 Baekhyun-dong, Bundang-gu, Sungnam, Gyeonggi-do 463-746, Republic of Korea;4. College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea;1. Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata 700064, India;2. Department of Agricultural Biotechnology, School of Agriculture and Rural Development, Ramakrishna Mission Vivekananda University, Ramakrishna Mission Ashram Narendrapur, Kolkata 700103, India;3. AICRP on Groundnut, Directorate of Research, Bidhan Chandra Krishi Viswavidyalaya, Kalyani, Nadia, West Bengal 741235, India;1. G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoku 159, Vladivostok 690022, Russian Federation;2. Far Eastern Federal University, Suhanova Street 8, Vladivostok 690950, Russian Federation;3. Institute of Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoku 159, Vladivostok 690022, Russian Federation;1. School of Pharmacy and Bioengineering, Chengdu University, Chengdu 610106, China;2. School of Medicine and Nursing, Chengdu University, Chengdu 610106, China;1. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China;2. Department of Phytochemistry, Second Military Medical University, Shanghai 200433, PR China;3. Key Laboratory of Animal Parasitology, Ministry of Agriculture, Shanghai Veterinary Research Institute, Shanghai, PR China;1. Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia;2. Laboratory of Natural Products, Institute of Biosience, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia;3. Makna Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia |
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| Abstract: | In our continuing search for bioactive constituents from Korean medicinal sources, an investigation of the Sinomenium acutum Rehder et Wilson rhizome afforded three new lignan derivatives (1⿿3) together with nine known compounds (4⿿12). The identification and structural elucidation of these new compounds were based on 1D and 2D-NMR (COSY, HMQC, HMBC and NOESY) and MS data. The absolute configurations were established based on the CD data. Nitric oxide production was evaluated in the BV-2 lipopolysaccharide-activated microglia cell line to investigate the anti-neuroinflammatory effects of the isolated compounds (1⿿12). |
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| Keywords: | Menispermaceae Lignan Neuroprotection Anti-neuroinflammation |
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