New nor-clerodane-type furanoditerpenoids from the rhizomes of Tinospora capillipes |
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| Institution: | 1. Department of Natural Product Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China;2. The Second Hospital of Shandong University, 247 Bei-Yuan Street, Jinan 250033, PR China |
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| Abstract: | Three new nor-clerodane-type furanoditerpenoids, tinocapillins A–C (1–3), and three known diterpenoids were isolated from the rhizomes of Tinospora capillipes. Their structures were elucidated on the basis of extensive spectroscopic analysis. The absolute configuration of compound 4 was established by single-crystal X-ray diffraction analysis using Cu Kα radiation. Compounds 1, 2, and 5 exhibited moderate inhibitory activity on the proliferation of the A549, Hep G2, Hela, and OS-RC-2 human cancer cell lines. |
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| Keywords: | Nor-clerodane furanoditerpenoids Tinocapillins A–C Anti-proliferative activity |
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