| 门静脉海绵样变大鼠门静脉氧化应激损伤的研究 |
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| 引用本文： | 王建尧,刘磊,姚君,王斌,陈芳,毛建雄,缪小平,林飞飞.门静脉海绵样变大鼠门静脉氧化应激损伤的研究[J].现代生物医学进展,2010,10(6). |
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| 作者姓名： | 王建尧 刘磊 姚君 王斌 陈芳 毛建雄 缪小平 林飞飞 |
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| 作者单位： | 1. 遵义医学院深吉儿童医院普外科,广东,深圳,518026
2. 暨南大学附属第二医院,广东,深圳,518026 |
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| 基金项目： | 深圳市卫生局科技项目(200650) |
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| 摘 要： | 目的:考察门静脉海绵样变性(CTPV,Cavernous transformation of portal vein)大鼠体内氧化应激的状态以及氧化应激对门静脉结构的影响。方法:采用门脉部分结扎法复制CTPV大鼠动物模型;通过测定门静脉内血浆超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)的活力来分析机体抗氧化能力,测定丙二醛(MDA)含量分析机体氧化能力;门静脉HE染色观察门静脉病理变化。结果:Sham组大鼠门静脉造影显示门静脉通畅,无曲张与扩张;门静脉病理学检查显示门静脉管腔无增大、内皮细胞光滑、中膜平滑肌层无增厚、外膜完整。CTPV组大鼠门静脉造影显示门静脉周围侧支循环形成,门静脉病理检查显示多个管腔大小不一、外形不规则血管腔,管腔之间为较狭窄的纤维性间隔,其内可见脂肪细胞、散在的淋巴细胞及肥大细胞等,门静脉管腔增大、血管内膜受损、内皮细胞脱落、中膜平滑肌增厚和血栓形成。与Sham组大鼠比较,CTPV组大鼠SOD、GSH-Px活性降低(93.79+8.87μU/L Vs103.05+8.07μU/L,P<0.05,157.44+26.46U/ml Vs709.09+83.21U/ml,P<0...
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| 关 键 词： | 门静脉海绵样变性 氧化应激 |
The study on oxidative stress damage of portal vein involved in cavernous transformation of portal vein rats |
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| WANG Jian-yao,LIU Lei,YAO Jun,WANG Bin,CHEN Fang,MAO Jian-xiong,MIAO Xiao-ping,LIN Fei-fei.The study on oxidative stress damage of portal vein involved in cavernous transformation of portal vein rats[J].Progress in Modern Biomedicine,2010,10(6). |
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| Authors: | WANG Jian-yao LIU Lei YAO Jun WANG Bin CHEN Fang MAO Jian-xiong MIAO Xiao-ping LIN Fei-fei |
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| Institution: | WANG Jian-yao1,LIU Lei1,YAO Jun2,WANG Bin1,CHEN Fang1,MAO Jian-xiong1,MIAO Xiao-ping1,LIN Fei-fei1 (1 Department of General Surgery,Shenzhen Children\'s Hospital,Shenzhen (518026,Guangdong Province,China,2 The Second Affiliated Hospital of Jinan University,Shenzhen 518026,China) |
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| Abstract: | Objective: This study was designed to investigate oxidative stress status of cavernous transformation of portal vein (CTPV) and the influence of oxidative stress to structure of portal vein.Methods: The cavernous transformation of portal vein rat model was prepared by partial portal-vein ligation.Antioxidant capacities were evaluated by assaying activities of superoxide dismutase (SOD),glutathione peroxidase(GSH-Px) in the portal vein blood.The content of malonaldehyde (MDA),maker of lipid peroxidation,was ... |
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| Keywords: | The cavernous transformation of portal vein(CTPV) oxidative stress |
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