Tilescope: online analysis pipeline for high-density tiling microarray data |
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| Authors: | Zhengdong D Zhang Joel Rozowsky Hugo YK Lam Jiang Du Michael Snyder Mark Gerstein |
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| Institution: | (1) Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA;(2) Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA;(3) Department of Computer Science, Yale University, New Haven, CT 06520, USA;(4) Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA |
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| Abstract: | We developed Tilescope, a fully integrated data processing pipeline for analyzing high-density tiling-array data . In a completely automated fashion, Tilescope will normalize signals between channels and across arrays, combine replicate
experiments, score each array element, and identify genomic features. The program is designed with a modular, three-tiered
architecture, facilitating parallelism, and a graphic user-friendly interface, presenting results in an organized web page,
downloadable for further analysis. |
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