Hypothyroidism in the fetal and neonatal rat does not impair the insulin secretory response to glucose |
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Authors: | I Swenne |
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Institution: | Department of Medical Cell Biology, Biomedicum, P.O. Box 571. S-751 23 Uppsala, Sweden |
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Abstract: | Fetal and neonatal hypothyroidism was induced by treating pregnant rats with propylthiouracil (PTU) in the drinking water from day 12 of gestation to day 7 postnatally. The serum levels of thyroxine and triiodothyronine were lowered in both mother and offspring and the neonates showed a 20% reduction in weight gain. An i.p. glucose tolerance test on the 7-day old neonates revealed no major disturbances in glucose tolerance or insulin response. The data suggest that thyroid hormones are not essential for the neonatal development of the B-cell secretory response to glucose. |
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