| 杀菌肽的研究进展及应用前景 |
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| 引用本文： | 崔晓江,刘枝俏,田颖川,彭学贤. 杀菌肽的研究进展及应用前景[J]. 生物化学与生物物理进展, 1995, 22(1): 5-8 |
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| 作者姓名： | 崔晓江 刘枝俏 田颖川 彭学贤 |
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| 作者单位： | 中国科学院微生物研究所;中国医学科学院基础医学研究所;中国科学院微生物研究所;中国科学院微生物研究所 |
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| 摘 要： | 杀菌肽是在昆虫体内诱导产生的一类具有强抗菌活性的、由30多个氨基酸组成的多肽.它的特殊空间结构可以使原核细胞膜形成孔洞，导致细胞死亡，对真核细胞膜却无此作用.哺乳动物体内亦存在类似的有抗菌活性的多肽，杀菌肽因其广谱杀菌活性而引起了植物学家和医学家的注意.已被用于植物抗病原菌和医学研究.
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| 关 键 词： | 杀菌肽 细胞膜 广谱杀菌 |
| 收稿时间： | 1994-01-19 |
| 修稿时间： | 1994-04-07 |
Advances in the Research of Antibacterial Peptides and the Prospects of Their Application |
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| Cui Xiaojiang,Liu Zhiqiao,Tian Yingchuan and Peng Xuexian. Advances in the Research of Antibacterial Peptides and the Prospects of Their Application[J]. Progress In Biochemistry and Biophysics, 1995, 22(1): 5-8 |
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| Authors: | Cui Xiaojiang Liu Zhiqiao Tian Yingchuan Peng Xuexian |
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| Affiliation: | Institute of microbiology, Academia Sinica;Institute of microbiology, Academia Sinica;Institute of microbiology, Academia Sinica;Institute of microbiology, Academia Sinica |
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| Abstract: | Cecropins and other related peptides are induced in insects and composed of over 30 amino acids with strong antibacterial activity,which is due to formation of large pores in bacterial cell membranes by their specific secondary structure. Analogs of these peptides which do no harm to eukaryotic cell membrances in lethal concentrations for bacteria have been found in mammalian cells. Owing to their broad antibacterial activity,cecropins and other peptides have brought attention of plant pathologists and medical scientists and been applied to the research of medicine and plant antibacterial infection. |
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| Keywords: | cecropin cell membrane antibacterial activity amphipathic |
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