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Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis
Affiliation:1. Department of Microbial Pathogenesis and Immunology, Texas A&M Health, College of Medicine, Bryan, TX 77807, USA;2. Department of Molecular and Cellular Medicine, Texas A&M Health, College of Medicine, Bryan, TX 77807, USA;3. Department of Microbiology, Biochemistry & Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103, USA;4. Department of Veterinary Pathobiology, Texas A&M College of Veterinary Medicine and Biomedical Sciences, College Station, TX 77843, USA;5. Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA 70433, USA;6. Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA
Abstract:
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  • Keywords:LRRK2  pyroptosis  inflammation  inflammasome  Parkinson’s disease  innate immunity  RIPK3  immunometabolism
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