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An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity
Institution:1. Harvard Medical School, Boston, MA, USA;2. Boston Children’s Hospital, Division of Immunology, Boston, MA, USA;3. Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy;4. Howard Hughes Medical Institute, Division of Genetics, Brigham and Women’s Hospital, Program in Virology, Boston, MA, USA;5. Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, Los Angeles, CA, USA;6. Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA, USA;7. University of Maryland School of Medicine, Department of Microbiology and Immunology, Baltimore, MD, USA;8. Brigham and Women’s Hospital, Division of Allergy and Clinical Immunology, Boston, MA, USA;9. Department of Biotechnology and Biosciences, University of Milano—Bicocca, Milan, Italy;10. Center for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science, Tokyo, Japan;11. Department of Otolaryngology—Head and Neck Surgery, Department of Cell, Developmental & Cancer Biology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA;12. Department of Biomedical Sciences, Quillen College of Medicine, Center of Excellence in Inflammation, Infectious Disease and Immunity, East Tennessee State University, Johnson City, TN, USA;13. Department of Surgery, Quillen College of Medicine, Center of Excellence in Inflammation, Infectious Disease and Immunity, East Tennessee State University, Johnson City, TN, USA;14. Boston Children’s Hospital, Precision Vaccines Program, Boston, MA, USA;15. Dana-Farber Cancer Institute, Department of Cancer Biology, Boston, MA, USA;16. Broad Institute of MIT & Harvard, Cambridge, MA, USA;17. Massachusetts Institute of Technology, Department of Biological Engineering and Department of Materials Science and Engineering, Koch Institute for Integrative Cancer Research, Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA;18. Howard Hughes Medical Institute, Chevy Chase, MD, USA;19. Boston Children’s Hospital, Division of Gastroenterology, Boston, MA, USA
Abstract:
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  • Keywords:inflammation  innate immunity  pattern recognition receptor  PRR  pathogen-associated molecular pattern  PAMP  interferon  Dectin  viral glycoprotein  influenza A virus  coronavirus  SARS-CoV-2
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