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LGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma
Affiliation:1. Department of Systems Immunology, Weizmann Institute, Rehovot, Israel;2. Rheumatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel;3. Rheumatology Institute, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion-Israeli Institute of Technology, Haifa, Israel;4. Flow Cytometry Unit, Department of Biological Services, Weizmann Institute, Rehovot, Israel;5. Department of Bone Marrow Transplantation, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel;6. Dermatology Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel;7. Plastic Surgery Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel;8. Institue of Pulmonology Medicine, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel;9. Orthopedic Department, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel;10. The Department of Veterinary Resources, Weizmann Institute, Rehovot, Israel;11. Life Sciences Core Facilities, Weizmann Institute, Rehovot, Israel;12. Department of Biological Regulation, Weizmann Institute, Rehovot, Israel;13. Rheumatology Institute at the Tel Aviv Sourasky Medical Center, Tel Aviv-Yafo, Israel
Abstract:
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  • Keywords:autoimmune  systemic sclerosis  fibroblast  LGR5  skin  GVHD  TWIST1  FOS  fibrosis
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