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Tumor-reactive antibodies evolve from non-binding and autoreactive precursors
Affiliation:1. Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel;2. Department of Biological Regulation, Weizmann Institute of Science, Rehovot 7610001, Israel;3. Faculty of Engineering, Bar Ilan University, Ramat Gan 52900, Israel;4. Department of Life Sciences and Core Facilities, Weizmann Institute of Science, Rehovot 7610001, Israel;5. Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel;6. Gynecologic Oncology Division, Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel;7. Department of Pathology, Rabin Medical Center, Petah Tikva, Israel;8. Davidoff Cancer Center, Rabin Medical Center, Petah Tikva, Israel;9. The Sackler School of Medicine, Tel Aviv University, Tel Aviv-Yafo, Israel;10. Department of Mathematics and Computer Science, Weizmann Institute of Science, Rehovot 7610001, Israel;11. Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv-Yafo, Israel
Abstract:
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  • Keywords:antibodies  B cells  antibody-mediated immune response  ovarian cancer  cancer  autoantibodies  MMP14  MT1-MMP  plasma cells  HGSOC
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