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Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses
Institution:1. Center for Infectious Disease and Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, USA;2. Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA;3. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA;4. Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA;5. Galveston National Laboratory, Galveston, TX, 77550, USA;6. Division of Pathobiological Sciences, University of Wisconsin, Madison, WI 53706, USA;7. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA;8. Virology Division, United States Army Research Institute for Infectious Disease, Fort Detrick, Frederick, MD 21702, USA;9. Zalgen Labs, Germantown, MD 20876, USA;10. Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA;11. Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA;12. Department of Microbiology and Immunology, Division of Virology, Institute of Medical Science, Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan;13. Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Abstract:
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  • Keywords:antibody therapeutic  Bundibugyo virus  cryo-EM  Ebola virus  ebolavirus  medical countermeasure  monoclonal antibody  nonhuman primate  Sudan virus
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