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Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches
Institution:1. Laboratory of Myeloid Cell Biology in Tissue Homeostasis and Regeneration, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium;2. Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Belgium;3. Hepatology Research Unit, Department Internal Medicine and Pediatrics, Liver Research Center, Ghent University, Belgium;4. Gut-Liver Immunopharmacology Unit, Department of Basic and Applied Medical Sciences, Liver Research Center, Ghent University, Belgium;5. Laboratory of Myeloid Cell Biology in Tissue Damage and Inflammation, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium;6. Data Mining and Modelling for Biomedicine, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium;7. Department of Applied Mathematics, Computer Science and Statistics, Faculty of Science, Ghent University, Ghent, Belgium;8. VIB BioImaging Core, VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent 9052, Belgium;9. Laboratory of Immunology, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine, Ghent University, Belgium;10. Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), Université Libre de Bruxelles (ULB), Brussels, Belgium;11. ULB Institute of Neuroscience (UNI), Université Libre de Bruxelles (ULB), Brussels, Belgium;12. WELBIO, Université Libre de Bruxelles (ULB), Brussels, Belgium;13. Center for Medical Genetics Ghent, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium;14. KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Molecular Vaccinology and Vaccine Discovery, Leuven, Belgium;15. Laboratory of Parasitology, Department of Translational Physiology, Infectiology and Public Health, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium;16. Laboratory of Systems Biology and Genetics, Institute of Bioengineering, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland;17. Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland;18. Oncode Institute, Department of Cell and Chemical Biology, Leiden Medical Center, Leiden, Netherlands;19. Department of Pathology, Ghent University Hospital, Ghent 9000, Belgium;20. Department of General and Hepatopancreatobiliary Surgery and Liver Transplantation, Ghent University Hospital, Ghent 9000, Belgium;21. Department of Human Structure and Repair, Ghent University Hospital, Ghent 9000, Belgium;22. Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent 9000, Belgium
Abstract:
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