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Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes
Affiliation:1. Max Planck Institute for Molecular Genetics, Berlin, Germany;2. Institute for Medical and Human Genetics, Charité Universitätsmedizin Berlin, Berlin, Germany;3. Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany;4. Institute of Human Genetics, University of Montpellier, CNRS, Montpellier, France;5. Dipartimento di Fisica, Università di Napoli Federico II and INFN Napoli, Complesso Universitario di Monte Sant''Angelo, Naples, Italy;6. Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA;7. Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA;8. Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine, Berlin, Germany;9. Charité-Universitätsmedizin Berlin, BCRT-Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany;10. Centro Andaluz de Biología del Desarrollo (CABD), Consejo Superior de Investigaciones Científicas/Universidad Pablo de Olavide, Seville, Spain;11. Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK;12. Museum für Naturkunde, Leibniz Institute for Evolution and Biodiversity Science, Berlin, Germany;13. Broad Institute of MIT and Harvard, Cambridge, MA, USA;14. Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK
Abstract:
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  • Keywords:topologically associating domains  lamina-associated domain  enhancer-promoter specificity  DNA methylation  developmental gene regulation  evolution  loop extrusion  cohesin  CTCF  3D genome organization
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