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Dissecting the treatment-naive ecosystem of human melanoma brain metastasis
Affiliation:1. Department of Medicine, Division of Hematology/Oncology, and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA;2. Program for Mathematical Genomics, Columbia University, New York, NY 10032, USA;3. Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA;4. Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, USA;5. Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA;6. Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA;7. Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, 69120 Heidelberg, Germany;8. Department of Oncology UNIL CHUV, Lausanne Branch, Ludwig Institute for Cancer Research Lausanne, CHUV and University of Lausanne, Lausanne, 1066 Épalinges, Switzerland;9. Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland;10. Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA;11. Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA;12. Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA;13. Department of Neurological Surgery, New York Presbyterian/Columbia University Irving Medical Center, New York, NY 10032, USA;14. Department of Cancer Immunology and Virology, Dana-Farber Cancer Center, Boston, MA 02215, USA;15. Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA;16. Division of Hematology/Oncology, Medstar Washington Cancer Institute, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA;17. Department of Surgery, University of Virginia, Charlottesville, VA, USA;18. Department of Dermatology, Eberhard Karls University Tübingen, 72076 Tübingen, Germany;19. Charité—Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Dermatology, Venereology and Allergology, 10117, Berlin, Germany;20. Department of Melanoma Medical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA;21. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;22. Department of Pharmacology, Weill Cornell Graduate School, New York, NY 10065, USA;23. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;24. Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA;25. Irving Institute for Cancer Dynamics, Columbia University, New York, NY 10027, USA;26. Department of Medicine, Jonsson Comprehensive Cancer Center, University of California, Los Angeles (UCLA), Los Angeles, CA 90024, USA;27. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA;28. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA;29. Institute of Pathology, Heidelberg University Hospital, 69120 Heidelberg, Germany;30. Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA;31. Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
Abstract:
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