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H2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions
Authors:Manching Ku  Jacob D Jaffe  Richard P Koche  Esther Rheinbay  Mitsuhiro Endoh  Haruhiko Koseki  Steven A Carr  Bradley E Bernstein
Affiliation:1. Department of Pathology, Center for Systems Biology and Center for Cancer Research, Massachusetts General Hospital, Simches Research Building, CPZN 8234, Boston, MA, 02114, USA
2. Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD, 20815-6789, USA
3. Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, MA, 02142, USA
4. Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA
5. Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E25-519, Cambridge, MA, 02139, USA
6. Bioinformatics Program and Department of Biomedical Engineering, Boston University, 24 Cummington Street, Boston, MA, 02215, USA
7. RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan
Abstract:
Keywords:Acetylation, bivalent, ChIP-Seq, H2A.Z, mass spectrometry   ubiquitination
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