Mislocalization of the exitatory amino-acid transporters (EAATs) in human astrocytoma and non-astrocytoma cancer cells: effect of the cell confluence |
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| Authors: | Karine Varini Amal Benzaria Nadira Taïeb Coralie Di Scala Amanda Azmi Soraya Graoudi Marc Maresca |
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| Institution: | 1.Interactions cellulaires neuroimmunes et pathologies du système nerveux central, CRN2M, CNRS UMR 6231, University of Aix-Marseille 2 and Aix-Marseille 3, Faculté de Médecine - Secteur Nord, Université de la Méditerranée, Marseille, France;2.Aix-Marseille Université, Faculté des Sciences de St-Jérôme, 13397 Marseille Cedex 20, France |
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| Abstract: | Background Astrocytomas are cancers of the brain in which high levels of extracellular glutamate plays a critical role in tumor growth
and resistance to conventional treatments. This is due for part to a decrease in the activity of the glutamate transporters,
i.e. the Excitatory Amino Acid Transporters or EAATs, in relation to their nuclear mislocalization in astrocytoma cells. Although
non-astrocytoma cancers express EAATs, the localization of EAATs and the handling of L-glutamate in that case have not been
investigated. |
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| Keywords: | Astrocytoma Cancer GLAST GLT-1 Glutamate EAAT Mislocalization STTG-1 |
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