The potassium channel opener cromakalim (BRL 34915) activates ATP-dependent K+ channels in isolated cardiac myocytes |
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| Authors: | D Escande D Thuringer S Leguern I Cavero |
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| Affiliation: | Laboratory of Cellular Electrophysiology, Rh?ne-Poulenc Santé, Gennevilliers, France. |
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| Abstract: | In cardiac myocytes, cromakalim (BRL 34915), a potassium channel opener, activates a time-independent K+ current exhibiting poor voltage-sensitivity. This effect of cromakalim is antagonized by low concentrations of glibenclamide, a specific blocker of ATP-dependent K+ channels in cardiac cells. Direct recording of the activity of K+ channels in inside-out membrane patches, confirmed that cromakalim is a potent activator of ATP-dependent K+ channels in cardiac myocytes. |
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