Novel spiroanellated 1,2,4-trioxanes with high in vitro antimalarial activities |
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| Authors: | Griesbeck Axel G El-Idreesy Tamer T Höinck Lars-Oliver Lex Johann Brun Reto |
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| Affiliation: | 1. Namık Kemal University, Faculty of Medicine, Department of Pharmacology, 59030 Tekirdag, Turkey;2. Kocaeli University, Faculty of Medicine, Department of Histology and Embryology, Umuttepe 41380, Kocaeli, Turkey;3. Kocaeli University, Faculty of Medicine, Department of Physiology, Umuttepe 41380, Kocaeli, Turkey;4. Kocaeli University, Faculty of Medicine, Department of Pharmacology and Experimental Medical Research and Application Unit, Umuttepe 41380, Kocaeli, Turkey |
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| Abstract: | A remarkable increase in antimalarial in vitro activity was achieved by integration of spiroadamantane motifs in 6-alkylidene 1,2,4-trioxanes 3a-h via diastereoselective photooxygenation of allylic alcohols and subsequent BF(3)-catalyzed peroxyacetalization with adamantanone to give the active compounds 3e-h. |
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