S-Allylcysteine reduces breast tumor cell adhesion and invasion |
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Authors: | Gapter Leslie A Yuin Ong Zhan Ng Ka-Yun |
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Affiliation: | Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Building S4, Singapore 117543, Republic of Singapore |
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Abstract: | Previous studies show that aqueous garlic extract and its derivatives (e.g. S-allylcysteine [SAC]) prevent carcinogen-induced breast tumorigenesis. However, investigations testing the effect of SAC on later stages of breast tumorigenesis and/or metastasis have produced mixed results. Here we show that SAC significantly reduced anchorage-dependent and -independent growth of MDA-MB-231 breast tumor cells in a dose- and time-dependent fashion, and sub-lethal SAC-treatment altered mammary tumor cell adhesion and invasion through components of the extracellular matrix. We provide evidence to suggest increased expression of E-cadherin and reduced MMP-2 expression and activity are partially responsible for inhibition of mammary tumor cell invasion by SAC. Because E-cadherin and MMP-2 are important in cancer metastasis, these results suggest a link between SAC induction of E-cadherin and reduction of MMP2 activity with the inhibition of cell motility and invasion; thus providing evidence that events leading to breast cancer metastasis are repressed by sub-lethal SAC-treatment. |
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Keywords: | Breast cancer E-cadherin Garlic Matrix metalloprotease Metastasis MDA-MB-231 MMP SAC S-Allylcysteine Tumor growth |
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