Senescence marker protein 30 (SMP30)/regucalcin (RGN) expression decreases with aging, acute liver injuries and tumors in zebrafish |
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| Authors: | Fujisawa Koichi Terai Shuji Hirose Yoshikazu Takami Taro Yamamoto Naoki Sakaida Isao |
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| Affiliation: | aCenter for Reparative Medicine, Yamaguchi University School of Medicine, Minami Kogushi 1-1-1, Ube Yamaguchi 755-8505, Japan;bDepartment of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Minami Kogushi 1-1-1, Ube Yamaguchi 755-8505, Japan;cDivision of Laboratory, Yamaguchi University Hospital, Minami-Kogushi 1-1-1, Ube Yamaguchi 755-8505, Japan |
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| Abstract: | Senescence marker protein 30 (SMP30)/regucalcin (RGN) is known to be related to aging, hepatocyte proliferation and tumorigenesis. However, expression and function of non-mammalian SMP30/RGN is poorly understood. We found that zebrafish SMP30/RGN mRNA expression decreases with aging, partial hepatectomy and thioacetamide-induced acute liver injury. SMP30/RGN expression was also greatly decreased in a zebrafish liver cell line. In addition, we induced liver tumors in adult zebrafish by administering diethylnitrosamine. Decreased expression was observed in foci, hepatocellular carcinomas, cholangiocellular carcinomas and mixed tumors as compared to the surrounding area. We thus showed the importance of SMP30/RGN in liver proliferation and tumorigenesis. |
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| Keywords: | Zebrafish Liver tumors Aging Senescence marker protein 30 (SMP30) Regucalcin |
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