Anti-tumor activity of the farnesyl-protein transferase inhibitors arteminolides, isolated from Artemisa |
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Authors: | Lee Seung Ho Lee Mi-Young Kang Hyun-Mi Han Dong Cho Son Kwang-Hee Yang Deok Cho Sung Nack-Do Lee Chang Woo Kim Hwan Mook Kwon Byoung-Mog |
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Institution: | Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yoosunggu, Taejeon 305-600, South Korea. |
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Abstract: | Members of the Artemisia genus are important medicinal plants found throughout the world. Arteminolides A-D (1-4), isolated from the aerial parts of Artemisia, have an inhibitory activity on farnesyl-protein transferase (FPTase; EC 2.5.1.29) in in vitro assay. This study was carried out with the purpose of validating anti-tumor effects of the compounds in human tumor cells and mouse xenograft model. The arteminolides inhibited tumor cell growth in a dose-dependent manner. Furthermore, arteminolide C (3) blocked in vivo growth of human colon and lung tumor xenograft without the loss of body weight in nude mice. |
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