Antihemolytic and antioxidant activities of <Emphasis Type="Italic">Allium paradoxum</Emphasis> |
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Authors: | Mohammad Ali Ebrahimzadeh Seyed Fazel Nabavi Seyed Mohammad Nabavi Bahman Eslami |
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Institution: | (1) Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan;(2) Research Center for Medicinal Plant Resources, Tsukuba Division, 1-2 Yawata-dai, Tsukuba 305-0843, Japan;(3) National Institute of Health Sciences (NIHS), 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan |
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Abstract: | Antioxidant activity of the aerial part and bulbs of Allium paradoxum was investigated by eight in vitro assay systems. Extracts showed good antioxidant activity. IC50 for 1,1-diphenyl-2-picryl hydrazyl radical-scavenging activity was 890.9±43.2 and 984.9±33.5 μg/ml for the aerial part and
bulbs, respectively. The aerial parts have better reducing power than bulb extracts but not comparable with Vitamin C (P>0.001).
Extracts showed weak Fe2+ chelating ability, the IC50 being 959±47 and 530±24 μg/ml for bulbs and aerial parts, respectively. Both tested extracts exhibited good hydrogen peroxide
scavenging in a concentration dependent manner. They exhibited good antioxidant activity against the hemoglobin-induced linoleic
acid system that was comparable with vitamin C (P>0.01). They showed good activity against cumene hydro peroxide induced hemolysis
in RBCs. In addition, they possessed antihemolytic activity. The extract from aerial parts had significantly higher total
phenol and flavonoid content than did bulbs. Amounts of eight elements (Cu, Mn, Zn, Fe, Ni, Pb, Cd and Cr) were also determined
in the bulb and aerial part using atomic absorption spectroscopy. They contained higher Fe and Mn contents than other elements. |
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