Exploring the HME and HAE1 efflux systems in the genus Burkholderia |
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Authors: | Elena Perrin Marco Fondi Maria Cristiana Papaleo Isabel Maida Silvia Buroni Maria Rosalia Pasca Giovanna Riccardi Renato Fani |
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Affiliation: | (1) Lab. of Molecular and Microbial Evolution, Dep. of Evolutionary Biology, University of Florence, Via Romana 17-19, 50125 Firenze, Italy;(2) Dep. of Genetics and Microbiology, University of Pavia, Via Ferrata 1, 27100 Pavia, Italy |
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Abstract: | Background The genus Burkholderia includes a variety of species with opportunistic human pathogenic strains, whose increasing global resistance to antibiotics has become a public health problem. In this context a major role could be played by multidrug efflux pumps belonging to Resistance Nodulation Cell-Division (RND) family, which allow bacterial cells to extrude a wide range of different substrates, including antibiotics. This study aims to i) identify rnd genes in the 21 available completely sequenced Burkholderia genomes, ii) analyze their phylogenetic distribution, iii) define the putative function(s) that RND proteins perform within the Burkholderia genus and iv) try tracing the evolutionary history of some of these genes in Burkholderia. |
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