Assignment of the gene coding for human cytochrome c oxidase subunit VIb to chromosome 19, band q13.1, by fluorescence in situ hybridisation |
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| Authors: | Jan-Willem Taanman Anneke Y. van der Veen Cobi Schrage Hans de Vries Charles H. C. M. Buys |
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| Affiliation: | (1) Laboratory of Physiological Chemistry, University of Groningen, Bloemsingel 10, NL-9712 KZ Groningen, The Netherlands;(2) Department of Medical Genetics, University of Groningen, Ant. Deusinglaan 4, NL-9713 AW Groningen, The Netherlands |
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| Abstract: | Summary A cloned, 40 kb, genomic DNA fragment, containing the last exon of the gene for human cytochrome c oxidase subunit VIb and its flanking sequences, was used as a probe to localize the subunit VIb gene on human metaphase chromosomes. The probe was labelled with Bio-11-dUTP and detected by fluorescence. Subsequent R-banding indicated that the cytochrome c oxidase subunit VIb gene is localized in band 19q13.1, extending the evidence that the human nuclear genes of cytochrome c oxidase are not clustered. |
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