Analysis of a circular code model

A circular code has been identified in the protein (coding) genes of both eukaryotes and prokaryotes by using a statistical method called trinucleotide frequency (TF) method Arquès & Michel (1996). J. theor. Biol. 182, 45-58]. Recently, a probabilistic model based on the nucleotide frequencies with a hypothesis of absence of correlation between successive bases on a DNA strand, has been proposed by Koch & Lehmann (1997). J. theor. Biol. 189, 171-174] for constructing some particular circular codes. Their interesting method which we call here nucleotide frequency (NF) method, reveals several limits for constructing the circular code observed with protein genes.