Hepatic expression of cytochrome P450 enzymes in non‐human primate species |
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| Authors: | Shotaro Uehara Yasuhiro Uno Hiroshi Yamazaki |
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| Institution: | 1. Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Tokyo, Japan;2. Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd., Kainan, Wakayama, Japan;3. Laboratory of Translational Research, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan |
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| Abstract: | Cytochromes P450 (P450) largely remain to be characterized in great apes. Comparative immunochemical detection of drug metabolizing forms of P450s 1A, 2A, 2B, 2C, 2D, 2E, 2J, 3A, 4A, and 4F in liver microsomes from chimpanzees, gorillas, orangutans, gibbons, cynomolgus and rhesus macaques, and common marmosets were carried out. |
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| Keywords: | drug‐metabolizing activity great apes immunoblotting primates |
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