A significant productive in vivo infection of resting cells with simian immunodeficiency virus in a macaque with AIDS |
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Authors: | Bapi Pahar Wendy Lala Dot Kuebler David Liu |
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Affiliation: | Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, USA |
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Abstract: | Identifying the cells that can be infected with HIV in vivo and thus potentially persist as latent reservoirs is of high priority. Here, we report the major infected cells in a chronically simian immunodeficiency virus (SIV)‐infected macaque that developed AIDS and encephalitis. A majority of the infected cells were detected as non‐proliferating resting cells. SIV‐infected non‐proliferating resting cells were found to be playing an important role in viral pathogenesis, persistence, or reservoir formation. |
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Keywords: | infection macrophage reservoir resting cells simian immunodeficiency virus simian immunodeficiency virus RNA T cells |
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