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Clinical heterogeneity in the tricho-dento-osseous syndrome |
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| Authors: | F. Quattromani S. D. Shapiro R. S. Young R. J. Jorgenson J. W. Parker R. Blumhardt R. R. Reece |
| Affiliation: | 1. Department of Radiology, 2nd General Hospital, D-6790, Landstuhl, Federal Republic of Germany 2. Department of Periodontics and Genetics School of Dentistry, University of Texas Health Science Center, 78284, San Antonio, TX, USA 3. Department of Pediatrics, Brooke Army Medical Center, 78284, Fort Sam Houston, TX, USA 4. the Department of Radiology, Brooke Army Medical Center, 78284, Fort Sam Houston, TX, USA 5. Department of Radiology, William Beaumont Army Medical Center, 79901, El Paso, TX, USA |
| Abstract: | The tricho-dento-osseous syndrome (TDO syndrome) involves morphologic abnormalities of hair, teeth, and skeleton. Clinical findings of the TDO syndrome are excessively curly (fuzzy) hair, enamel hypoplasia, and skeletal findings of a generalized pattern of osseous sclerosis. We report an autosomal dominant syndrome with similar hair and teeth morphology, but with a skeletal dysplasia consisting of sclerosis and thickening of the calvarium with long bones that show subtle undertubulation but no sclerosis. |
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