Applications of NMR to structure-based drug design in structural genomics |
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Authors: | Powers Robert |
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Institution: | (1) Department of Biological Chemistry, Wyeth Research, 87 Cambridge Park Dr., Cambridge, Massachusetts, 02140, U.S.A |
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Abstract: | Structural genomics is poised to have a tremendous impact on traditional structure-based drug design programs. As a result, there is a growing need to obtain rapid structural information in a reliable form that is amenable to rational drug design. In this manner, NMR has been expanding and evolving its role in aiding the design process. A variety of NMR methodologies that cover a range of inherent resolution are described in the context of structure-based drug design in the era of structural genomics. |
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