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Chitooligosaccharides induce apoptosis of human hepatocellular carcinoma cells via up-regulation of Bax
Authors:Qingsong Xu   Jiangli Dou   Peng Wei   Chengyu Tan   Xiaojing Yun   Yihong Wu   Xuefang Bai   Xiaojun Ma  Yuguang Du  
Affiliation:

aDalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China

bGene Research Center, Shanghai Medical College of Fudan University, Shanghai 200032, China

cGraduate School of Chinese Academy Sciences, Beijing 100049, China

Abstract:Chitooligosaccharides (COS) have been shown to regulate various cellular and biological functions. However, the effect of COS on apoptosis of hepatocellular carcinoma cells remains unclear. In this study, the activity and mechanism of COS against human hepatocellular carcinoma cells (SMMC-7721 cells) were investigated in vitro. The experiments showed that COS notably induced the apoptosis of SMMC-7721 cells and increased the cleavage of poly(ADP-ribose) polymerase. It presented a dose-dependent manner, and the apoptotic rate amounted to about 38% after treatment with 0.8 mg/ml COS for 72 h. The mRNA and protein levels of Bax were up-regulated by COS. These results demonstrated that COS induced apoptosis of SMMC-7721 cells. The possible mechanism is that COS up-regulate pro-apoptotic protein Bax, and trigger the cells a start-up of the apoptosis program.
Keywords:Chitooligosaccharides   Hepatoma   Apoptosis   Bax
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