Increased intrathecal high-avidity anti-tau antibodies in patients with multiple sclerosis |
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Authors: | Fialová Lenka Bartos Ales Svarcová Jana Malbohan Ivan |
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Institution: | Institute of Medical Biochemistry, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic. |
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Abstract: | BackgroundAntibodies against tau protein indicate an interaction between the immune system and the neurocytoskeleton and therefore may reflect axonal injury in multiple sclerosis (MS).Methodology/Principal FindingsThe levels and avidities of anti-tau IgG antibodies were measured using ELISA in paired cerebrospinal fluid (CSF) and serum samples obtained from 49 MS patients and 47 controls. Anti-tau antibodies were significantly elevated intrathecally (p<0.0001) in the MS group. The CSF anti-tau antibody levels were lower in MS patients receiving therapy than those without treatment (p<0.05). The avidities of anti-tau antibodies were higher in the CSF than in the serum (MS group p<0.0001; controls p<0.005). Anti-tau avidities in the CSF were elevated in MS patients in comparison with controls (p<0.05), but not in serum.ConclusionsMS patients have higher levels of intrathecal anti-tau antibodies. Anti-tau antibodies have different avidities in different compartments with the highest values in the CSF of MS patients. |
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