Effect of High-Intensity Interval Training on Cardiac Apoptosis Markers in Methamphetamine-Dependent Rats |
| |
Authors: | Hadi Shahrabadi Amir Hossein Haghighi Roya Askari Majid Asadi-Shekaari Daniel Costa Souza Paulo Gentil |
| |
Institution: | 1.Department of Exercise Physiology, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar 9617976487, Iran; (H.S.); (R.A.);2.Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman 7619813159, Iran;3.College of Physical Education and Dance, Federal University of Goias, Goiania 74690-900, Brazil; (D.C.S.); (P.G.);4.Hypertension League, Federal University of Goias, Goiania 74690-900, Brazil;5.Instituto VIDA, Brasilia 70673-464, Brazil |
| |
Abstract: | Chronic methamphetamine use increases apoptosis, leading to heart failure and sudden cardiac death. Previous studies have shown the importance of high-intensity interval training (HIIT) in reducing indices of cardiac tissue apoptosis in different patients, but in the field of sports science, the molecular mechanisms of apoptosis in methamphetamine-dependent rats are still unclear. The present article aimed to investigate the changes in cardiac apoptosis markers in methamphetamine-dependent rats in response to HIIT. Left ventricular tissue was used to evaluate caspase-3, melusin, FAK, and IQGAP1 gene expression. Rats were divided into four groups: sham, methamphetamine (METH), METH-control, and METH-HIIT. METH was injected for 21 days and then the METH-HIIT group performed HIIT for 8 weeks at 5 sessions per week. The METH groups showed increased caspase-3 gene expression and decreased melusin, FAK, and IQGAP1 when compared to the sham group. METH-HIIT showed decreased caspase-3 and increased melusin and FAK gene expression compared with the METH and METH-control groups. The IQGAP1 gene was higher in METH-HIIT when compared with METH, while no difference was observed between METH-HIIT and METH-control. Twenty-one days of METH exposure increased apoptosis markers in rat cardiac tissue; however, HIIT might have a protective effect, as shown by the apoptosis markers. |
| |
Keywords: | interval training heart cell death drug abuse aerobic exercise exercise is medicine |
|
|