| 碱性成纤维细胞生长因子研究进展 |
| |
| 引用本文： | 孙钦策,田卫东.碱性成纤维细胞生长因子研究进展[J].生物磁学,2009(15):2947-2949,2973. |
| |
| 作者姓名： | 孙钦策 田卫东 |
| |
| 作者单位： | [1]四川大学生命科学学院,四川成都610065 [2]四川大学华西口腔医学院,四川成都610065 |
| |
| 基金项目： | 基金项目：教育部博士点基金项目（2007061064）;国家重大科学计划项目（2010CB94480） |
| |
| 摘 要： | 碱性成纤维细胞生长因子是细胞生长和分化的重要调节因子,具有促血管生成、细胞增殖、细胞趋化、细胞迁移等活性,在细胞分化和机体发育过程中发挥重要作用。碱性成纤维细胞生长因子通过与细胞膜表面的特异性配体结合,进而引发细胞内的一系列级联反应,从而产生各种生物学效应。本文对碱性成纤维细胞生长因子的生物学基础、信号转导、生物学功能以及临床应用研究进展作一综述。
|
| 关 键 词： | 碱性成纤维细胞生长因子 受体 信号转导 生物学功能 |
The research advances of Basic fibroblast growth factor |
| |
| SUN Qin-ce,TIAN Wei-dong.The research advances of Basic fibroblast growth factor[J].Biomagnetism,2009(15):2947-2949,2973. |
| |
| Authors: | SUN Qin-ce TIAN Wei-dong |
| |
| Institution: | 1 College of life science, Sichuan Universi(y, Chengdu, 610065, China 2 West China College ofStomatology Sichuan University, Chengdu, 610065, China) |
| |
| Abstract: | Basic fibroblast growth factor （FGF-2） is an important modulator of cell growth and differentiation under both physio- logical and pathological conditions. FGF-2 is known to induce chemotaetic, angiogenic, and mitogenic activity and plays an important role in early differentiation and developmental processes. Via binding its specific transmembrane receptors （fibroblast growth factor re- ceptors, FGFRs）, FGF-2 activates the subsequent intracellular second messenger cascades and leads to diverse biological effects. This pa- per describes the biological substructure of FGF-2, signal transduction and its biological functions. |
| |
| Keywords: | FGF-2 Receptors Signal transduction Biological functions |
| 本文献已被 维普 等数据库收录！ |
|
