| 骨唾液酸蛋白在乳腺癌骨转移中的研究进展 |
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| 引用本文： | 燕慧,王捷.骨唾液酸蛋白在乳腺癌骨转移中的研究进展[J].生物磁学,2009(16):3176-3178. |
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| 作者姓名： | 燕慧 王捷 |
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| 作者单位： | [1]广州军区广州总医院医学实验科,广东广州510010 [2]华南理工大学生物科学与工程学院,广东广州510006 |
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| 基金项目： | 基金项目：广东省自然科学基金重点项目（编号：06104396） |
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| 摘 要： | 骨唾液酸蛋白（Bonesialoprotein，BSP）是细胞外基质中一种高度磷酸化和糖基化分泌性蛋白，它是多种癌症（乳腺癌，前列腺癌和肺癌等）进程中的重要参与者。乳腺癌细胞转染实验和裸鼠移植模型证明过表达BSP可以促进乳腺癌细胞骨转移。BSP抗体和反义核酸均可有效抑制乳腺癌细胞骨转移的发生，故BSP有可能成为一种新的诊断和治疗乳腺癌骨转移的靶蛋白。
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| 关 键 词： | 骨唾液酸蛋白 乳腺癌 骨转移 |
Research progress of bone sialoprorein in bone metastasis induced by breast cancer cells |
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| YAN Hui,WANG Jie.Research progress of bone sialoprorein in bone metastasis induced by breast cancer cells[J].Biomagnetism,2009(16):3176-3178. |
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| Authors: | YAN Hui WANG Jie |
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| Institution: | 1 Center of Medical Research, Liuhuaqiaol Hospital of Guangzhou Military, Guangzhou, 510010, China; 2 South China University of Technology, School Of Bioscience And Bioengineering, Guangzhou, 510006) |
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| Abstract: | Bone sisloprotein （BSP）is one of the advanced phosphorylate and glycosylate secreted proteins in the extra cellular matrix which is the important participator in many cancer progressions （such as breast cancer, prostate cancer and lung cancer ）.Breast cancer cells transfection experiment and nude mouse transplantation model demonstrate over-express BSP can promote bone metastasis of breast cancer cells. Antibody against BSP and antisense oligodeoxynucleotides （ASOs） both inhibit bone metastasis of breast cancer cells, so BSP may be a new targeted protein in the diagnosis and treatment of bone metastasis. |
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| Keywords: | Bone sialoprotein Breast cancer Bone metastasis |
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