系统性红斑狼疮患者血清MBL水平变化及其临床意义

目的：研究系统性红斑狼疮（SLE）患者外周血中甘露糖结合凝集素（MBL）水平与SLE的临床表现、经典的血清学指标及疾病活动性指数的相关性。方法：应用固相酶联免疫吸附（ELISA）法检测54例（其中活动期39例、缓解期15例）SLE患者和45名健康志愿者外周血MBL水平，同时检测SLE患者外周血抗dsDNA抗体、C3补体、白细胞计数及循环免疫复合物（CICs）水平，并记录SLE患者主要临床症状（肾脏系统受累、神经系统受累、严重感染等），疾病活动度用SLEDAI记分。结果：系统性红斑狼疮患者外周血MBL水平显著低于健康志愿者（P〈0．01）；特别是活动期SLE患者血清MBL水平明显降低，与缓解组比较差别具有统计学意义（P〈0．01）；SLE患者血清MBL水平与SLEDAI、抗dsDNA抗体、CICs水平呈负相关，与白细胞计数及C3补体水平呈正相关；并发严重感染的SLE患者组血清MBL水平显著低于无受累组（P〈0．01）。结论：SLE患者血清MBL水平明显降低，血清MBL水平与SLEDAI、抗dsDNA抗体、C3水平、CIC水平、白细胞水平之间明显相关，血清MBL水平较低的患者更易发生比较严重的感染，血清MBL水平可能是SLE潜在生物学标记。

Level and clinical significance of MBL in SLE patients

Objective： To investigate the change of serum level of mannose binding lectin （MBL） in systemic lupus erythematosus （SLE） patients and the relationship with clinical symptoms, classical serum makers and disease activity indices, and to explore the role of MBL in the pathogenesis of SLE. Methods： ELISA was used to analyze the serum levels of MBL in 54 patients with SLE （26 active and 28 inactive cases） and 45 health volunteers. The serum levels of anti-dsDNA antibody, complement C3, leucocyte count and circulating immune complexes（CICs） were also determined. At the same time, the main clinical symptoms of SLE patients were registered, including kidney, the nervous system damaged and severe infections. Results： The serum levels of MBL in SLE patients were significantly lower than those of health volunteers（P〈0.01 ）, especially the active cases. Serum MBL levels were correlated inversely with SLEDAI, the levels of anti-dsDNA antibody, CICs, and correlated positively with the levels of complement C3 and leucocyte count. Serum MBL levels in SLE patients with severe infections were significantly lower than those without severe infections. Conclusion： Serum MBL levels correlate intensively with the condition of SLE patients and it may be a potential biomarker of disease activity in SLE patients.