溴氰菊酯致大鼠DNA损伤及对肝功能的影响

目的：研究溴氰菊酯（DM）对大鼠外周血淋巴细胞DNA的损伤作用及对肝脏功能的影响。方法：32只雌性Wistar大鼠随机分成4组，染毒剂量分别为0，3．125，6．250，12．500mg／kg，连续灌胃染毒10天。DNA损伤采用单细胞凝胶电泳（彗星实验）进行评价，并测定丙氨酸氨基转移酶（ALT）以反映肝功能变化。结果：染毒组大鼠外周淋巴细胞的尾DNA％（Tail DNA％）、尾矩（Tail Moment）和Olive尾矩（Olive Tail Moment）均高于对照组（P〈0．05），差别有统计学意义。各染毒组与对照组的肝功能差异均无统计学意义。结论：DM可导致外周血淋巴细胞DNA损伤。

Effect of Deltamethrin on DNA Damage and Liver Function in Rats

Objective： To investigate the effect of dettamethrin on rat lymphocytes DNA damage and liver function. Methods： 32 female Wistar rats were randomly divided into four groups. The deltamethrin exposure doses were separately 0, 3.125, 6.250, 12.500 mg/kg by gavage for ten days. DNA damage was detected by Single cell gel electrophoresis （Comet assay） and liver function was evaluated by alanine aminotransferase assay. Results： Tail DNA percentage,Tail Moment and Olive Tail Moment of peripheral lymphocytes in rats exposed by deltamethrin were higher than that in control group. Liver function indexes had no significant differences between test group and control group. Conclusions： Peripheral lymphocytes DNA damage was induced by deltamethrin without the changes of liver function under the experimental condition.